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No question, really - just wanted to say thanks for evangelizing this topic. I'm originally a medical doctor who converted to the ways of computer science, now a founder in the bio space. One thing I've consistently wrestled with is how to structurally defend our company's ability to "first, do no harm." I think the misguided incentives you raise warning about are also the primary reason for the defects we see in our (American) healthcare system today, particularly with the grievances toward big pharma and the insurance industry. So I was pumped watching your interview with Garry a few weeks back, currently working on applying it to our own little lemonade stand.


thank you!

Healthcare is a recurring topic in the book, for the reasons you specify. In fact, I call for the adoption of a Director's Oath similar to the Hippocratic Oath for boards. They can do just as much - or even more - harm.


Hey guys, this is my github repo. Glad it's received some interest - I figured HN might be the culprit when it suddenly jumped ~100 stars despite not working on the code base since last year. I prototyped this out of personal curiosity last year and moved on abruptly so there's a lot of gaps I still need to close and knobs that need to be optimized. But if people genuinely find "deterministic genomics workloads on edge devices" proposal useful, I'll begin refining the code tonight and try to make it as useful as possible. If you have any particular bioinformatics tasks or use cases that you want to be feasible on edge devices, lmk and I'll work on integrating new capabilities. Always happy to be helpful


Your website bio and LinkedIn don't match at all. Is the LinkedIn link on your website wrong? Update: yes it is. This is the correct one: https://www.linkedin.com/in/logan-nye

You're doing too much vibe coding and not enough checking/testing.

LinkedIn link on your website points to: https://linkedin.com/in/logannye

Website bio: https://www.logannye.io/about


they weren't expecting to receive attention out of the blue today. it seems rude to attack someone's engineering skills because an online profile is out of date.


It's not out of date, it's pointing at the wrong person.


this isn't an attack. this is a data point that they don't review the slop coming out of the LLLM


oh wow lol never seen that one before


I'll echo this by saying that, as someone who has their MD, there is much we simply do not know. We're always updating our priors and have much to base our decisions off of, but we simply do not understand many things. Medicine is out here winging it with the best of intentions, but there are no "experts" in the grand scheme of things.


2swap makes some fantastic videos, I'd recommend giving them a follow on YT if you enjoy math visualizations. They also seem to spend quite a bit of time on the audio for each upload


The 2swap lambda calculus video (https://www.youtube.com/watch?v=RcVA8Nj6HEo) is a masterpiece!


I recently went to a poker night during SF tech week and realized I'm not good at Texas Hold 'em. I wanted a way to improve that doesn't require me losing $100-200 every week, so I built this to get better between weekly poker nights. UI/UX is still very early, so any feedback that helps me make it more useful/delightful are appreciated. If you're in SF, hope to see you at one of the (many) weekly poker nights around the bay!


Currently working on https://tinyZKP.com

It's an API that allows zero-knowledge proofs to be generated in a streaming fashion, meaning ZKPs that use way less RAM than normal.

The goal is to let people create ZKPs of any size on any device. ZKPs are very cool but have struggled to gain adoption due to the memory requirements. You usually need to pay for specialized hardware or massive server costs. Hoping to help fix the problem for devs


This looks really interesting! Where would you suggest a beginner go to learn more about ZKPs and their applications?

I’d love to play with simple ZKP algos.


Fwiw: the website is brand new and very much in the "hot garbage" phase of development. I'm not a front-end guy, so critique is welcome from all - especially any bugs in the UX. I'm still actively uncovering them


that's cool. if would be great if you can add real-world examples for use-cases on the main page.


good idea, will add some this weekend


Missed opportunity to title this "Lo-RAgrets"


FWIW: I created a github repo for compact zero-knowledge proofs that could be useful for privacy-preserving ML models of reasonable size (https://github.com/logannye/space-efficient-zero-knowledge-p...). Unfortunately, FHE's computational overhead is still prohibitive for running ML workloads except on very small models. Hoping to help make ZKML a little more practical.


This sounds super interesting. Can you elaborate on how you apply ZK to ML? (or can you point me to any resources?)


Did you check Zama.ai's work on FHE?


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